Effect of a voluntary food fortification policy on folate, related B vitamin status, and homocysteine in healthy adults.
نویسندگان
چکیده
BACKGROUND Mandatory folic acid fortification of food is effective in reducing neural tube defects and may even reduce stroke-related mortality, but it remains controversial because of concerns about potential adverse effects. Thus, it is virtually nonexistent in Europe, albeit many countries allow food fortification on a voluntary basis. OBJECTIVE The objective of the study was to examine the effect of a voluntary but liberal food fortification policy on dietary intake and biomarker status of folate and other homocysteine-related B vitamins in a healthy population. DESIGN The study was a cross-sectional study. From a convenience sample of 662 adults in Northern Ireland, those who provided a fasting blood sample and dietary intake data were examined (n = 441, aged 18-92 y). Intakes of both natural food folate and folic acid from fortified foods were estimated; we used the latter to categorize participants by fortified food intake. RESULTS Fortified foods were associated with significantly higher dietary intakes and biomarker status of folate, vitamin B-12, vitamin B-6, and riboflavin than were unfortified foods. There was no difference in natural food folate intake (range: 179-197 microg/d) between the fortified food categories. Red blood cell folate concentrations were 387 nmol/L higher and plasma total homocysteine concentrations were 2 micromol/L lower in the group with the highest fortified food intake (median intake: 208 microg/d folic acid) than in the nonconsumers of fortified foods (0 microg/d folic acid). CONCLUSIONS These results show that voluntary food fortification is associated with a substantial increase in dietary intake and biomarker status of folate and metabolically related B vitamins with potential beneficial effects on health. However, those who do not consume fortified foods regularly may have insufficient B vitamin status to achieve the known and potential health benefits.
منابع مشابه
Long-term effects of folic acid fortification and B-vitamin supplementation on total folate, homocysteine, methylmalonic acid and cobalamin in older adults.
OBJECTIVE To investigate the long-term effects of the Canadian folic acid fortification program in older adults' whole blood cell folate (folate) and cobalamin (Cbl) status, including homocysteine (tHcy) and methylmalonic acid (MMA), with and without voluntary B-vitamin intake, from 1997 to 2004. METHODS Cohort of community-dwelling volunteer older adults. Clinical and biochemical data, inclu...
متن کاملبررسی سطح هموسیستیین تام
Introduction: Elevated plasma total homocysteine is an independent risk factor for cardiovascular disease and a sensitive marker of vitamin B12 and folate insufficiency. Folate and vitamin B12 have a protective effect on cardiovascular disease. This effect may be partly explained by mechanisms independent of homocysteine. This survey is the first population based study to evaluate the plasma ...
متن کاملImpact of voluntary fortification and supplement use on dietary intakes and biomarker status of folate and vitamin B-12 in Irish adults.
BACKGROUND Ireland has traditionally operated a liberal policy of voluntary fortification, but little is known about how this practice, along with supplement use, affects population intakes and status of folate and vitamin B-12. OBJECTIVE The aim was to examine the relative impact of voluntary fortification and supplement use on dietary intakes and biomarker status of folate and vitamin B-12 ...
متن کامل21st National Nutrient Databank Conference Poster Abstracts Poster 1- Category:databases in Epidemiological Studies Folate Fortification of Bread and Grains: Intake of the Elderly Is Affected by Food Sources of Folate
POSTER 1CATEGORY:DATABASES IN EPIDEMIOLOGICAL STUDIES FOLATE FORTIFICATION OF BREAD AND GRAINS: INTAKE OF THE ELDERLY IS AFFECTED BY FOOD SOURCES OF FOLATE. K.M. Koehler, S.L. Pareo-Tubbeh, L.J. Romero, R.N. Baumgartner, P.J. Garry, Univ. of New Mexico School of Medicine, Albuquerque, NM. Folate fortification of breads & grains will be implemented to prevent neural tube birth defects. This coul...
متن کاملاثر نان غنی شده با فولات بر وضعیت هوموسیستیین، فولات و ویتامین 12B افراد هیپرهوموسیستیینیمیک 70-60 ساله: مطالعه هوموسیستیین تهران
Background: Fortification of corn with folic acid has beneficial effects on hyperhomocysteinemia and heart disease. Folate fortification was contributed to an increase in average folate status and a reduction in serum homocysteine concentration. Methods: In this randomized clinical trial 17 men and women aged 61±5 years old with hyperhomocysteinemia with mean homocysteine concentration of 15/32...
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ورودعنوان ژورنال:
- The American journal of clinical nutrition
دوره 86 5 شماره
صفحات -
تاریخ انتشار 2007